Ancillary: Compound Reference

PDE5 inhibitor. Used for erectile dysfunction and blood pressure management. Low-dose daily use popular in bodybuilding for pumps and cardiovascular benefits.

Effects: Lowers blood pressure (mild), improves endothelial function, no significant impact on hormones or liver enzymes, does not affect lipids, can mildly lower haematocrit through improved blood flow. Generally blood-marker neutral.

Biguanide oral anti-diabetic. Used in bodybuilding to manage insulin sensitivity, especially alongside GH and MK-677. Also studied for longevity benefits.

Effects: Lowers fasting glucose and HbA1c, improves insulin sensitivity, can mildly lower LDL and triglycerides, may reduce B12 levels with long-term use, does not affect liver enzymes (may actually improve them), does not affect hormones

Amino acid derivative involved in fatty acid transport into mitochondria. Injectable form used in bodybuilding for fat metabolism, androgen receptor upregulation, and fertility support. Also available orally but with poor bioavailability.

Effects: Enhances fatty acid oxidation, may upregulate androgen receptor density, improves sperm quality and motility, supports insulin sensitivity, no significant impact on standard blood panels, mild injection site irritation possible

Small-molecule NNMT inhibitor. Blocks nicotinamide N-methyltransferase to boost NAD+ levels and activate SIRT1. Used for fat loss and metabolic support. Not a peptide but commonly grouped with them.

Effects: May improve metabolic markers: preserve NAD+ levels, enhance fat oxidation. May mildly affect lipids (improved profile through metabolic activation). No significant direct impact on hormones, liver enzymes, or haematology in limited data.

Puregon (follitropin beta) is a recombinant FSH (follicle-stimulating hormone) produced in CHO cells. Used in males to restore spermatogenesis after AAS-induced azoospermia or in hypogonadotropic hypogonadism. Always used alongside HCG (which provides LH activity).

Effects: Directly elevates serum FSH (exogenous), stimulates Sertoli cells to support spermatogenesis, increases inhibin B and AMH, may slightly increase estradiol. Does NOT directly affect testosterone (FSH acts on Sertoli cells, not Leydig cells). When combined with HCG, restores full spermatogenesis.