SERMs: Compound Reference
Selective estrogen receptor modulators block estrogen at specific tissues (breast) while allowing it at others (bone, liver). Used for PCT to restore natural testosterone production and to treat or prevent gynecomastia on cycle without crushing overall estradiol levels.
SERMs (4)
Tamoxifen
Nolvadex. Selective estrogen receptor modulator. Used for PCT and gyno prevention.
Effects: Blocks estrogen at breast tissue (gyno prevention), actually raises estradiol levels, stimulates LH/FSH production (PCT), beneficial for lipids, can increase SHBG
Clomiphene
Clomid. SERM used for PCT to restore natural testosterone production.
Effects: Stimulates LH/FSH (HPTA recovery), raises testosterone, can cause mood/vision sides at high doses, raises estradiol
Raloxifene
Evista. Second-generation SERM. Preferred over Tamoxifen for gynecomastia treatment and reversal due to stronger breast tissue selectivity.
Effects: Blocks estrogen at breast tissue (more effective for existing gyno than Tamoxifen), weaker LH/FSH stimulation than Tamoxifen (less useful for PCT), beneficial for lipids, positive effect on bone density, does not raise SHBG as significantly as Tamoxifen
Enclomiphene
Trans-isomer of Clomiphene. Stimulates LH/FSH for HPTA recovery without the estrogenic side effects of zuclomiphene (the cis-isomer).
Effects: Stimulates LH/FSH (HPTA recovery), raises endogenous testosterone, significantly fewer estrogen-related side effects than Clomiphene (no vision disturbances, less mood impact), does not significantly worsen lipids
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