GLP-1 Agonists: Compound Reference
GLP-1 receptor agonists (semaglutide, tirzepatide) reduce appetite and improve insulin sensitivity. Increasingly used by bodybuilders for fat loss phases and to manage GH-induced insulin resistance. Require monitoring of kidney function, pancreatic markers, and thyroid function.
GLP-1 Agonists (4)
Semaglutide
GLP-1 receptor agonist. Ozempic (injection) / Wegovy (weight loss) / Rybelsus (oral). Used in bodybuilding for appetite suppression and fat loss during cutting phases.
Effects: May mildly affect liver enzymes (typically improvement with fat loss), significant appetite suppression, improves fasting glucose and HbA1c, improves lipid profile (lower triglycerides, LDL), can cause mild elevations in amylase/lipase (monitor for pancreatitis), reduces CRP (anti-inflammatory)
Tirzepatide
Dual GIP/GLP-1 receptor agonist. Mounjaro / Zepbound. More potent fat loss than Semaglutide in clinical trials. Increasingly popular in bodybuilding for cutting.
Effects: Significant appetite suppression, improves fasting glucose and HbA1c (more potently than Semaglutide), improves lipid profile, may mildly affect liver enzymes (typically improvement), can elevate amylase/lipase, reduces CRP and inflammatory markers
Retatrutide
Triple agonist: GIP/GLP-1/Glucagon receptor agonist. Eli Lilly. Most potent weight loss peptide in clinical trials. Phase 3 trials ongoing.
Effects: Profound appetite suppression, improves fasting glucose and HbA1c, may improve lipid profile more than dual agonists (glucagon component increases energy expenditure), can elevate amylase/lipase, increased heart rate reported, may affect liver enzymes
Cagrilintide
Long-acting acylated amylin analog. Once-weekly injection. Promotes satiety, slows gastric emptying. Combined with Semaglutide as CagriSema for enhanced weight loss.
Effects: Significant appetite suppression, may improve fasting glucose and HbA1c (amylin reduces glucagon secretion), does not directly affect lipids or liver enzymes, GI side effects (nausea, vomiting) during titration are common
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