Enclomiphene

Trans-isomer of Clomiphene. Stimulates LH/FSH for HPTA recovery without the estrogenic side effects of zuclomiphene (the cis-isomer).

Overview

SERM

Trans-isomer of Clomiphene. Stimulates LH/FSH for HPTA recovery without the estrogenic side effects of zuclomiphene (the cis-isomer).

Effects on Markers

Stimulates LH/FSH (HPTA recovery), raises endogenous testosterone, significantly fewer estrogen-related side effects than Clomiphene (no vision disturbances, less mood impact), does not significantly worsen lipids

Compound Guide

Mechanism: Pure estrogen antagonist at the hypothalamus/pituitary. Unlike Clomiphene (Clomid) which is a 60:40 mix of enclomiphene:zuclomiphene, enclomiphene alone provides SERM activity without zuclomiphene's estrogenic agonist effects.

Dosage:

  • HPTA restart / PCT: 12.5-25mg/day for 4-8 weeks
  • Ongoing HPTA support: 6.25-12.5mg/day (some use low-dose long-term)
  • Fertility support: 12.5-25mg/day until sperm parameters recover

Administration:

  • Oral capsule/tablet, once daily in the morning
  • Can be run longer than traditional PCT SERMs due to cleaner side effect profile

Key Notes:

  • Preferred over Clomiphene (Clomid) by many — same LH/FSH stimulation without zuclomiphene's estrogenic sides
  • No vision disturbances (a known Clomid side effect from zuclomiphene)
  • Raises LH, FSH, and testosterone effectively — good PCT option alongside Tamoxifen
  • Some users run low-dose enclomiphene as a "testosterone optimisation" alternative to TRT
  • Available as a compounded medication in many countries (not widely available as a branded pharmaceutical yet)
  • Monitor: LH, FSH, total/free testosterone, E2 during PCT

How enclomiphene compares with HCG, lifestyle changes and replacement itself: TRT alternatives: a decision guide for low testosterone.

Usage History

Markers to Monitor

Pairs With

How Enclomiphene behaves when it is run alongside other compounds.

Commonly stacked with

Used to offset

Stacks the risk

Frequently Asked Questions

Quick Reference

Category

SERM

Half-Life

10 hours

Detection Time

N/A

Usage Summary