Enclomiphene
Trans-isomer of Clomiphene. Stimulates LH/FSH for HPTA recovery without the estrogenic side effects of zuclomiphene (the cis-isomer).
Overview
Trans-isomer of Clomiphene. Stimulates LH/FSH for HPTA recovery without the estrogenic side effects of zuclomiphene (the cis-isomer).
Stimulates LH/FSH (HPTA recovery), raises endogenous testosterone, significantly fewer estrogen-related side effects than Clomiphene (no vision disturbances, less mood impact), does not significantly worsen lipids
Compound Guide
Mechanism: Pure estrogen antagonist at the hypothalamus/pituitary. Unlike Clomiphene (Clomid) which is a 60:40 mix of enclomiphene:zuclomiphene, enclomiphene alone provides SERM activity without zuclomiphene's estrogenic agonist effects.
Dosage:
- HPTA restart / PCT: 12.5-25mg/day for 4-8 weeks
- Ongoing HPTA support: 6.25-12.5mg/day (some use low-dose long-term)
- Fertility support: 12.5-25mg/day until sperm parameters recover
Administration:
- Oral capsule/tablet, once daily in the morning
- Can be run longer than traditional PCT SERMs due to cleaner side effect profile
Key Notes:
- Preferred over Clomiphene (Clomid) by many — same LH/FSH stimulation without zuclomiphene's estrogenic sides
- No vision disturbances (a known Clomid side effect from zuclomiphene)
- Raises LH, FSH, and testosterone effectively — good PCT option alongside Tamoxifen
- Some users run low-dose enclomiphene as a "testosterone optimisation" alternative to TRT
- Available as a compounded medication in many countries (not widely available as a branded pharmaceutical yet)
- Monitor: LH, FSH, total/free testosterone, E2 during PCT
Usage History
Markers to Monitor
Frequently Asked Questions
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Quick Reference
Category
SERM
Half-Life
10 hours
Detection Time
N/A