Ipamorelin
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Overview
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Increases GH and IGF-1 levels, does not significantly raise cortisol or prolactin (unlike GHRP-2/6), minimal impact on appetite (unlike GHRP-6 and MK-677), may mildly elevate fasting glucose with prolonged use
Compound Guide
Structure: Pentapeptide GH secretagogue. Selective for GH release with minimal stimulation of cortisol, prolactin, or appetite pathways.
Dosage:
- Standard: 200-300mcg 2-3x/day (before meals or before bed)
- Combined with mod-GRF: 100mcg Ipamorelin + 100mcg mod-GRF per injection, 2-3x/day
- Anti-aging: 200mcg before bed
Administration:
- SubQ injection, 27-30g insulin syringe
- Best on empty stomach (30+ min before food)
- Pre-bed injection captures natural GH pulse during sleep
Key Notes:
- Cleanest GH secretagogue — no significant cortisol or prolactin increase (unlike GHRP-2 and GHRP-6)
- No significant hunger increase (unlike GHRP-6 and MK-677)
- Synergistic with GHRH analogs (mod-GRF, CJC-1295) — GHRH + GHRP together amplify GH release
- Multiple daily injections needed due to short half-life — less convenient than CJC-1295 DAC or MK-677
- Monitor: IGF-1, fasting glucose
- Very well tolerated — one of the best entry-level peptides for GH optimisation
- Reconstitute with bacteriostatic water, store refrigerated
Usage History
Marker Interactions
Frequently Asked Questions
Related Articles
How to Inject IM and SubQ: The Complete Guide for Every Site
Step-by-step injection guide covering every IM and SubQ site, needle selection by compound, Z-track technique, PIP prevention, and site rotation.
SARMs and Peptides Bloodwork: The Complete Monitoring Guide
What blood tests to get before, during, and after SARMs and peptides. Compound-by-compound risk matrix, testing timeline, and action thresholds.
MK-677 & Insulin Resistance: Full HOMA-IR and Glucose Data (2026)
MK-677 raises fasting glucose to 6.8 mmol/L within 4 weeks and HbA1c by 0.2% at 12 months. Complete HOMA-IR data from human studies, when the numbers cross into pre-diabetes, and 5 evidence-based fixes.
Quick Reference
Category
Peptide
Half-Life
~2 hours
Detection Time
N/A