Ipamorelin
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Overview
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Increases GH and IGF-1 levels, does not significantly raise cortisol or prolactin (unlike GHRP-2/6), minimal impact on appetite (unlike GHRP-6 and MK-677), may mildly elevate fasting glucose with prolonged use
Compound Guide
Structure: Pentapeptide GH secretagogue. Selective for GH release with minimal stimulation of cortisol, prolactin, or appetite pathways.
Dosage:
- Standard: 200-300mcg 2-3x/day (before meals or before bed)
- Combined with mod-GRF: 100mcg Ipamorelin + 100mcg mod-GRF per injection, 2-3x/day
- Anti-aging: 200mcg before bed
Administration:
- SubQ injection, 27-30g insulin syringe
- Best on empty stomach (30+ min before food)
- Pre-bed injection captures natural GH pulse during sleep
Key Notes:
- Cleanest GH secretagogue — no significant cortisol or prolactin increase (unlike GHRP-2 and GHRP-6)
- No significant hunger increase (unlike GHRP-6 and MK-677)
- Synergistic with GHRH analogs (mod-GRF, CJC-1295) — GHRH + GHRP together amplify GH release
- Multiple daily injections needed due to short half-life — less convenient than CJC-1295 DAC or MK-677
- Monitor: IGF-1, fasting glucose
- Very well tolerated — one of the best entry-level peptides for GH optimisation
- Reconstitute with bacteriostatic water, store refrigerated
Usage History
Marker Interactions
Frequently Asked Questions
Related Articles
Testosterone Esters Compared: Enanthate, Cyp, Nebido, Sus, Test 400
Compare every testosterone ester: enanthate, cypionate, propionate, Nebido, Sustanon, Test 400. Half-lives, doses, brand names, TRT vs blast.
Peptides for Loose Skin After Weight Loss: Evidence Protocol
Evidence-based 6-month peptide protocol for loose skin after weight loss: GHK-Cu, BPC-157, TB-500, CJC/ipamorelin, microneedling, red light, and bloodwork.
MK-677 and Blood Sugar: The Monitoring Protocol You Need
MK-677 raises fasting glucose in most users. Here's the evidence, the monitoring schedule, when to add metformin, and when to stop.
BPC-157 and TB-500: What the Evidence Actually Says
Evidence review of BPC-157 and TB-500 for recovery. Human trials, animal data, safety concerns, Australian legality, and what your bloodwork shows.
Quick Reference
Category
Peptide
Half-Life
~2 hours
Detection Time
N/A