Ipamorelin
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Overview
Selective growth hormone secretagogue peptide (GHRP). Cleanest GHRP with minimal cortisol and prolactin release. Often stacked with CJC-1295 or mod-GRF.
Increases GH and IGF-1 levels, does not significantly raise cortisol or prolactin (unlike GHRP-2/6), minimal impact on appetite (unlike GHRP-6 and MK-677), may mildly elevate fasting glucose with prolonged use
Compound Guide
Structure: Pentapeptide GH secretagogue. Selective for GH release with minimal stimulation of cortisol, prolactin, or appetite pathways.
Dosage:
- Standard: 200-300mcg 2-3x/day (before meals or before bed)
- Combined with mod-GRF: 100mcg Ipamorelin + 100mcg mod-GRF per injection, 2-3x/day
- Anti-aging: 200mcg before bed
Administration:
- SubQ injection, 27-30g insulin syringe
- Best on empty stomach (30+ min before food)
- Pre-bed injection captures natural GH pulse during sleep
Key Notes:
- Cleanest GH secretagogue — no significant cortisol or prolactin increase (unlike GHRP-2 and GHRP-6)
- No significant hunger increase (unlike GHRP-6 and MK-677)
- Synergistic with GHRH analogs (mod-GRF, CJC-1295) — GHRH + GHRP together amplify GH release
- Multiple daily injections needed due to short half-life — less convenient than CJC-1295 DAC or MK-677
- Monitor: IGF-1, fasting glucose
- Very well tolerated — one of the best entry-level peptides for GH optimisation
- Reconstitute with bacteriostatic water, store refrigerated
What to expect from your IGF-1 and glucose on this stack, with head-to-head data against MK-677: How to read your labs on CJC-1295 and ipamorelin.
Usage History
Pairs With
How Ipamorelin behaves when it is run alongside other compounds.
Commonly stacked with
Used to offset
Stacks the risk
Marker Interactions
Compare With
Ipamorelin vs MK-677 (Ibutamoren)
MK-677 vs Ipamorelin: GH secretagogue comparison for bodybuilders
Ipamorelin vs CJC-1295 no DAC (mod-GRF)
Ipamorelin vs CJC-1295 No-DAC: GHRP and GHRH explained
Ipamorelin vs Sermorelin
Sermorelin vs Ipamorelin: GHRH analog vs GHRP for IGF-1 elevation
Ipamorelin vs Hexarelin
Ipamorelin vs Hexarelin: Selective vs Non-Selective GHRP
Frequently Asked Questions
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Quick Reference
Category
Peptide
Half-Life
~2 hours
Detection Time
N/A