Testosterone Undecanoate (Oral)

Route: Oral. Testosterone undecanoate dissolved in oil, packaged in capsules. The long undecanoate chain plus the oil vehicle routes absorption through the intestinal lymphatic system instead of the portal vein, which is what allows an oral testosterone to work without wrecking the liver.

Absorption is entirely food dependent. Taken fasted it barely works. Every dose must be taken with a meal containing meaningful dietary fat.

Dosage:

• Andriol Testocaps (40 mg caps): 120-240 mg/day split across two or three doses with meals. Levels are erratic and frequently subtherapeutic
• Jatenzo (158/198/237 mg): 237 mg twice daily to start, titrated between 158 mg and 396 mg twice daily
• Kyzatrex / Tlando: similar twice-daily schedules per their own titration tables
• Never dose once daily. The circulating half-life is short and a single dose leaves you hypogonadal for most of the day

This is NOT a 17-alpha-alkylated oral. Unlike methyltestosterone or the classic oral AAS, it is not hepatotoxic by that mechanism. Do not lump it in with anavar or dianabol on liver risk.

Blood Pressure is the real warning:

• The modern formulations carry an explicit hypertension warning; average ambulatory systolic rises of several mmHg are typical and some users go considerably higher
• Check BP at baseline and again 4-6 weeks after starting or after any dose increase
• This, not the liver, is the reason to be cautious with oral TU

Bloodwork Timing:

• Draw roughly 4-6 hours after the morning dose, after at least 7-14 days on a stable dose
• Record the dose-to-draw interval and confirm the dose was taken with food, or the number means nothing
• Check DHT: the oral route pushes DHT and the DHT:T ratio higher than injectables
• Single draws are less reliable than for injectables because the daily curve is steep

Key Notes:

• The appeal is no needles and no transfer risk to partners or children
• Cost is the main practical barrier for the modern formulations; Andriol is cheaper but far less reliable
• Same HPTA suppression as any exogenous testosterone
• Not useful for enhancement dosing: the pharmacokinetics and the blood pressure ceiling both cap it well below what injectables achieve