Superdrol (Methasterone)
Potent oral AAS. 17-alpha alkylated. Known for rapid dry mass gains. One of the most liver-toxic oral AAS available.
Overview
Potent oral AAS. 17-alpha alkylated. Known for rapid dry mass gains. One of the most liver-toxic oral AAS available.
Severe liver stress (can cause cholestasis), dramatically worsens lipids, significantly elevates ALT/AST, does not aromatise, very strong HPTA suppression, causes lethargy from liver stress at higher doses
Compound Guide
Structure: 17-alpha alkylated, 2a,17a-dimethyl-5a-androstane-3-one-17b-ol. Marketed briefly as a "prohormone" but is a potent designer steroid.
Dosage:
- Conservative: 10mg/day for 3-4 weeks
- Moderate: 20mg/day for 3-4 weeks
- Advanced: 30mg/day for 3 weeks maximum (liver stress becomes extreme)
Administration:
- Oral capsule/tablet, split into 2 doses if possible
- NEVER exceed 4 weeks of continuous use
Key Notes:
- Produces dramatic dry, lean mass gains — 10-15 lbs in 3-4 weeks is common
- Extremely hepatotoxic — can cause intrahepatic cholestasis (bile duct obstruction)
- Lethargy and loss of appetite are hallmarks of Superdrol use (liver distress)
- Mandatory liver support: TUDCA 500-1000mg/day, NAC 1.5g/day throughout and 2 weeks after
- Monitor liver enzymes before, during, and after — ALT/AST can exceed 10x upper limit
- Does not aromatise — no water retention or estrogen sides
- Very strong HPTA suppression — proper PCT mandatory
- Not recommended for anyone with pre-existing liver issues
What the ALT, AST and GGT pattern tells you on a harsh oral, and when to stop: Liver enzymes on steroids: how to read your ALT, AST and GGT.
Usage History
Pairs With
How Superdrol (Methasterone) behaves when it is run alongside other compounds.
Used to offset
Stacks the risk
Marker Interactions
Frequently Asked Questions
Related Articles
Does Verve 102 Fix the Cholesterol Damage From Steroids?
A one-time gene edit cut LDL 62% in trial patients. Here is why it would not fix the lipid damage anabolic steroids actually cause.
On-Cycle Support Protocol: Every Supplement Mapped to Your Bloodwork
Evidence-based on-cycle support protocol with every supplement mapped to the blood markers it protects. Dosing, timing, and protocols by cycle type.
Best Cholesterol Supplements On Cycle, Ranked by Evidence (2026)
We ranked every cholesterol supplement by clinical effect size for steroid users: bergamot, fish oil, niacin, berberine, red yeast rice, and more. Exact doses, HDL vs LDL targets, and when a statin is the smarter call.
How to Protect Your Cholesterol on Steroids
Oral steroids crash HDL 50-70%. Compound rankings, on-cycle management protocol (cardio, omega-3, statins), and recovery timeline after you stop.
Quick Reference
Category
AAS
Half-Life
8-9 hours
Detection Time
Unknown (limited data)