Fertility Protocol
Restore or maintain spermatogenesis while on testosterone or recovering from a cycle
A fertility-focused protocol using HCG and HMG to stimulate both testosterone production and spermatogenesis. Can be run alongside TRT (no need to come off testosterone) or as a standalone recovery protocol. L-Carnitine is added for sperm quality. Timeline is 3-6 months as spermatogenesis takes ~74 days per cycle.
Compounds
Frequency: Mon / Wed / Fri
Mimics LH, stimulates Leydig cells (intratesticular testosterone + some spermatogenesis)
Frequency: Tue / Thu
Contains FSH + LH activity; directly stimulates Sertoli cells for sperm production
Dosage Summary: HCG 1000 IU MWF + HMG 75 IU Tue/Thu + L-Carnitine 400-600 mg/day
Supplements
L-Carnitine (injectable or oral)
400-600 mg/day
Zinc
25-50 mg/day
Folate
400-800 mcg/day
Vitamin D3
4000-5000 IU/day
CoQ10
200-400 mg/day
Selenium
200 mcg/day
Blood Marker Monitoring
| Marker | Frequency |
|---|---|
| Semen Analysis | Baseline, 3 months, 6 months |
| LH / FSH | Monthly for first 3 months |
| Total Testosterone | Monthly for first 3 months |
| Estradiol | Monthly (HCG can increase E2) |
Key Notes
- You do NOT need to come off TRT to run this protocol -- HCG + HMG can maintain fertility alongside exogenous testosterone
- Spermatogenesis takes ~74 days per cycle; expect 3-6 months for meaningful results
- If on TRT, consider reducing testosterone dose slightly (e.g. to 80-100 mg/week) to help
- HMG is the key addition over HCG alone -- it provides the FSH component that HCG lacks
- Injectable L-Carnitine (200-500 mg) is more bioavailable than oral but both work
- Get a baseline semen analysis before starting to track progress objectively
- High intratesticular estrogen from HCG is actually beneficial for spermatogenesis
After this protocol
Continue until fertility goals are achieved. Can maintain HCG at lower dose (500 IU 2-3x/week) long-term alongside TRT.
Frequently Asked Questions
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