VLDL Particle Size

Lipids marker

VLDL Size

VLDL Particle Size

Category: Lipids
Unit: nm

Mean diameter of VLDL particles. Larger VLDL particles are more triglyceride-rich and associated with insulin resistance and metabolic dysfunction.

PED Notes

GH use and insulin resistance increase VLDL size by promoting hepatic production of large triglyceride-rich VLDL. High-calorie bulking diets (especially high-carb) increase VLDL size. Larger VLDL particles are a key driver of the LP-IR insulin resistance score. Combined with insulin and GH use in advanced bodybuilding, VLDL size can be significantly elevated.

Supplements:

  • Omega-3 (EPA/DHA) -- 2-4g/day
  • Berberine -- 500mg 2-3x/day before meals

Lifestyle:

  • Reduce refined carbohydrates
  • If on GH, monitor VLDL size as insulin resistance marker
  • Regular cardio exercise
  • 12h fasted blood draw required for accurate measurement

References:

  • Shalaurova, I., Connelly, M. A., Garvey, W. T., & Otvos, J. D. (2014). Lipoprotein insulin resistance index. Metabolic Syndrome and Related Disorders, 12(8), 422-429. DOI: 10.1089/met.2014.0050
  • Mora, S., Otvos, J. D., Rifai, N., et al. (2009). Lipoprotein particle profiles by NMR in predicting incident CVD in women. Circulation, 119(7), 931-939. DOI: 10.1161/CIRCULATIONAHA.108.816181

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Frequently Asked Questions

Reference Ranges

Standard Range

35 - 55 nm

VitalMetrics Range

35 - 65 nm

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