Large HDL Particles
Lipids marker
Large HDL-P
Large HDL Particles
Concentration of large HDL particles. These are the most cardioprotective HDL subclass, responsible for the majority of reverse cholesterol transport.
PED Notes
AAS profoundly reduce large HDL-P — these particles are the first to decline on-cycle. Oral AAS have the most severe impact. Large HDL-P is the HDL subclass most associated with cardiovascular protection. On-cycle values often drop to near-zero. Recovery after cycle cessation is slow (3-6 months). Aerobic exercise is the strongest stimulus for large HDL-P production.
When low
Supplements:
- Omega-3 (EPA/DHA) -- 2-4g/day
- Niacin -- 500-1000mg extended-release (most effective for raising large HDL-P)
Lifestyle:
- Regular aerobic exercise 3-5x/week (strongest intervention)
- If large HDL-P near zero on-cycle, consider shortening cycle
- Post-cycle: prioritise cardio to accelerate HDL-P recovery
Educational information, not medical advice. Nothing here is a prescription or a treatment plan, and it does not account for your history, medications or conditions. Use it to ask better questions: bring it to your doctor and decide together. Full disclaimer.
History Chart
Reading History
Frequently Asked Questions
Reference Ranges
Standard Range
VitalMetrics Range