HDL Particle Size

Lipids marker

HDL Size

HDL Particle Size

Category: Lipids
Unit: nm

Mean diameter of HDL particles. Larger HDL particles are more cardioprotective, associated with better reverse cholesterol transport capacity.

PED Notes

AAS shrink HDL particles by reducing the proportion of large cardioprotective HDL. Smaller HDL is less effective at reverse cholesterol transport. Oral AAS have the most pronounced effect on HDL size. Regular aerobic exercise promotes larger HDL particles. HDL size typically recovers post-cycle alongside HDL-C and HDL-P.

Supplements:

  • Omega-3 (EPA/DHA) -- 2-4g/day
  • Niacin -- 500-1000mg extended-release (increases HDL size)

Lifestyle:

  • Regular aerobic exercise 3-5x/week (most effective)
  • If on oral AAS, monitor HDL size alongside HDL-C and HDL-P
  • Post-cycle: prioritise cardio to accelerate HDL recovery

References:

  • Mackey, R. H., Greenland, P., Goff, D. C., et al. (2012). HDL cholesterol and particle concentrations, carotid atherosclerosis, and coronary events: MESA. Journal of the American College of Cardiology, 60(6), 508-516. DOI: 10.1016/j.jacc.2012.03.038
  • Mora, S., Glynn, R. J., & Ridker, P. M. (2013). HDL cholesterol, size, particle number, and residual vascular risk after potent statin therapy. Circulation, 128(11), 1189-1197. DOI: 10.1161/CIRCULATIONAHA.113.002671

History Chart

Reading History

Frequently Asked Questions

Reference Ranges

Standard Range

8.8 - 10.5 nm

VitalMetrics Range

8.2 - 10.5 nm

Statistics