Anticardiolipin Antibody IgG
Inflammation marker
Cardiolipin IgG
Anticardiolipin Antibody IgG
An antiphospholipid antibody directed against cardiolipin. Together with anti-B2 glycoprotein I and lupus anticoagulant, it forms the laboratory criteria for antiphospholipid syndrome, a cause of thrombosis and pregnancy loss.
PED Notes
Anticardiolipin IgG is not affected by AAS, GH, or peptides, but the antiphospholipid syndrome it helps diagnose adds a strong, independent clotting drive on top of the thrombotic risk androgens already create through erythrocytosis and prothrombotic haemostatic changes. Moderate-to-high titre IgG carries more weight than low-level positivity. Criteria require persistent positivity confirmed at least 12 weeks apart, since transient positives occur with infections. Interpret against the laboratory's own cutoff. The bodybuilder range equals the standard range.
When high
When positive/elevated (above the assay cutoff):
- A positive anticardiolipin IgG, especially at medium-to-high titre and when persistent, supports antiphospholipid syndrome.
- What to do:
- Repeat testing at least 12 weeks later to confirm persistence; do not act on a single transient positive.
- Interpret alongside anti-B2 glycoprotein I and lupus anticoagulant; multiple positive tests (triple positivity) markedly increase clot risk.
- Seek haematology or rheumatology review with any thrombosis history, recurrent pregnancy loss, or unexplained thrombocytopenia.
- For AAS users, control haematocrit and discuss androgen safety and antithrombotic strategy with a clinician, as the risks are additive.
History Chart
Reading History
Frequently Asked Questions
Reference Ranges
Standard Range
VitalMetrics Range