Beta-2 Glycoprotein I Antibody IgG
Inflammation marker
Anti-B2 Glycoprotein I IgG
Beta-2 Glycoprotein I Antibody IgG
An antiphospholipid antibody targeting beta-2 glycoprotein I. It is one of the laboratory criteria for antiphospholipid syndrome, an autoimmune clotting disorder that causes venous and arterial thrombosis and pregnancy loss.
PED Notes
Anti-B2 glycoprotein I is not affected by AAS, GH, or peptides, but the condition it flags, antiphospholipid syndrome, is directly relevant to enhanced athletes because it compounds thrombotic risk. AAS already raise clot risk through erythrocytosis (high haematocrit) and a prothrombotic haemostatic shift; a positive antiphospholipid antibody adds an independent, powerful clotting drive. Anyone with an unexplained clot, especially a younger lifter, should be evaluated for antiphospholipid syndrome. Criteria require persistent positivity confirmed on repeat testing at least 12 weeks apart. Interpret against the laboratory's own cutoff. The bodybuilder range equals the standard range.
When high
When positive/elevated (above the assay cutoff):
- A positive anti-B2 glycoprotein I IgG is a marker of antiphospholipid syndrome, particularly when persistent and when found alongside anticardiolipin antibodies or a lupus anticoagulant.
- What to do:
- Confirm with repeat testing at least 12 weeks later; a single positive result can be transient (for example after infection).
- Seek specialist (haematology or rheumatology) review, especially with any history of venous or arterial thrombosis, recurrent miscarriage, or unexplained low platelets.
- For AAS users this is a serious compounding clot risk: keep haematocrit controlled and discuss the safety of continuing androgens and the need for antithrombotic management with a clinician.
History Chart
Reading History
Frequently Asked Questions
Reference Ranges
Standard Range
VitalMetrics Range