Tesamorelin
Synthetic GHRH (Growth Hormone Releasing Hormone) analog. FDA-approved for HIV-associated lipodystrophy. Used in bodybuilding for GH release and visceral fat reduction.
Overview
Synthetic GHRH (Growth Hormone Releasing Hormone) analog. FDA-approved for HIV-associated lipodystrophy. Used in bodybuilding for GH release and visceral fat reduction.
Increases GH and IGF-1 levels, may elevate fasting glucose mildly (less than exogenous GH), can improve lipid profile (reduces triglycerides), reduces visceral adipose tissue, may mildly affect thyroid function (monitor TSH/FT4)
Compound Guide
Structure: 44-amino-acid synthetic GHRH analog with a trans-3-hexenoic acid modification for increased potency. The only FDA-approved GHRH analog.
Dosage:
- Standard (FDA-approved): 2mg/day SubQ
- Bodybuilding (visceral fat / GH): 1-2mg/day
- Anti-aging / general: 1mg/day
Administration:
- SubQ injection, abdomen (rotate sites), once daily before bed or morning on empty stomach
- 27-30g insulin syringe
- Must be taken on empty stomach — food blunts GH release
Key Notes:
- Stimulates pulsatile GH release (more physiological than exogenous GH injections)
- FDA-approved with established safety profile — one of the better-studied peptides
- Specifically reduces visceral fat (the dangerous deep abdominal fat)
- Improves triglycerides and body composition in clinical trials
- Less impact on blood glucose than exogenous GH (preserves physiological feedback)
- Monitor: IGF-1, fasting glucose, HbA1c, lipid panel
- Can be combined with Ipamorelin for enhanced GH release
- Does not cause GH bleed (sustained high levels) like CJC-1295 DAC — more natural pulsatile pattern
The 26-week visceral fat data, the monitoring protocol, and how it compares with CJC and MK-677: How tesamorelin cuts visceral fat without raising blood sugar.
Usage History
Pairs With
How Tesamorelin behaves when it is run alongside other compounds.
Commonly stacked with
Used to offset
Stacks the risk
Marker Interactions
Compare With
Tesamorelin vs CJC-1295 no DAC (mod-GRF)
CJC-1295 No-DAC vs Tesamorelin: Both GHRH Analogs, Very Different Evidence Bases
Tesamorelin vs Sermorelin
Tesamorelin vs Sermorelin: Which GHRH to Pick, and Why Never Both
Tesamorelin vs MK-677 (Ibutamoren)
Tesamorelin vs MK-677: Glucose-Neutral Phase 3 Evidence vs Cheap Oral Glucose Cost
Tesamorelin vs Semaglutide
Tesamorelin vs Semaglutide: Two Different Axes for Visceral Fat on TRT
Frequently Asked Questions
Related Articles
How to Pick Your First Peptide and What to Add After That
Most peptide stacks fail on sequence, not selection. A six-stage roadmap for what to run first, what to add next, and what the evidence actually supports.
How to Test for Heavy Metals in UGL Steroids and Peptides
UGL steroids and grey-market peptides can carry lead, cadmium, and arsenic. Here is which blood tests to order and how to read the results.
Peak Week Carb Loading: Front Load, Back Load or Undulating
How to carb load and fill out for a bodybuilding show, the truth about water loading, electrolyte safety, and what your peak week bloodwork actually shows.
Does 5-Amino-1MQ Actually Burn Fat? (No Human Trials Yet)
5-amino-1MQ is an NNMT inhibitor sold for fat loss and NAD+. Here's the real evidence, honest dosing, and the bloodwork to run on it.
Quick Reference
Category
Peptide
Half-Life
26-38 minutes
Detection Time
N/A