Tesamorelin
Synthetic GHRH (Growth Hormone Releasing Hormone) analog. FDA-approved for HIV-associated lipodystrophy. Used in bodybuilding for GH release and visceral fat reduction.
Overview
Synthetic GHRH (Growth Hormone Releasing Hormone) analog. FDA-approved for HIV-associated lipodystrophy. Used in bodybuilding for GH release and visceral fat reduction.
Increases GH and IGF-1 levels, may elevate fasting glucose mildly (less than exogenous GH), can improve lipid profile (reduces triglycerides), reduces visceral adipose tissue, may mildly affect thyroid function (monitor TSH/FT4)
Compound Guide
Structure: 44-amino-acid synthetic GHRH analog with a trans-3-hexenoic acid modification for increased potency. The only FDA-approved GHRH analog.
Dosage:
- Standard (FDA-approved): 2mg/day SubQ
- Bodybuilding (visceral fat / GH): 1-2mg/day
- Anti-aging / general: 1mg/day
Administration:
- SubQ injection, abdomen (rotate sites), once daily before bed or morning on empty stomach
- 27-30g insulin syringe
- Must be taken on empty stomach — food blunts GH release
Key Notes:
- Stimulates pulsatile GH release (more physiological than exogenous GH injections)
- FDA-approved with established safety profile — one of the better-studied peptides
- Specifically reduces visceral fat (the dangerous deep abdominal fat)
- Improves triglycerides and body composition in clinical trials
- Less impact on blood glucose than exogenous GH (preserves physiological feedback)
- Monitor: IGF-1, fasting glucose, HbA1c, lipid panel
- Can be combined with Ipamorelin for enhanced GH release
- Does not cause GH bleed (sustained high levels) like CJC-1295 DAC — more natural pulsatile pattern
Usage History
Marker Interactions
Frequently Asked Questions
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Quick Reference
Category
Peptide
Half-Life
26-38 minutes
Detection Time
N/A