Sermorelin
Synthetic GHRH analog (GRF 1-29). Stimulates natural pulsatile GH release from the pituitary. Originally FDA-approved for paediatric GH deficiency. Used off-label for anti-aging and body composition.
Overview
Synthetic GHRH analog (GRF 1-29). Stimulates natural pulsatile GH release from the pituitary. Originally FDA-approved for paediatric GH deficiency. Used off-label for anti-aging and body composition.
Increases pulsatile GH and IGF-1 levels, may mildly elevate fasting glucose (less than exogenous GH), can cause subclinical hypothyroidism in ~6.5% of users (monitor TSH/FT4), generally well tolerated on blood markers
Compound Guide
Structure: Synthetic 29-amino-acid peptide representing the bioactive fragment of native GHRH (1-44). The shortest functional GHRH sequence.
Dosage:
- Anti-aging / body composition: 200-300mcg before bed
- Standard titration: 200mcg/day (weeks 1-2) → 300mcg (weeks 3-4) → 400-500mcg (weeks 5-8)
- Combined with GHRP: 200-300mcg Sermorelin + 100-200mcg Ipamorelin before bed
Administration:
- SubQ injection at bedtime (aligns with natural nocturnal GH pulse)
- 27-30g insulin syringe
- Empty stomach preferred
Key Notes:
- One of the best-studied GH peptides — was FDA-approved (as Geref) before discontinuation for commercial reasons
- Preserves natural GH pulsatility and feedback — more physiological than exogenous GH
- Less potent than Tesamorelin or mod-GRF/CJC-1295 but well-studied safety profile
- Can cause subclinical hypothyroidism (~6.5%) — monitor thyroid panel
- Synergistic with GHRPs (Ipamorelin, GHRP-2) — GHRH + GHRP together amplifies release
- Short half-life means single daily injection is practical (GH pulse occurs within minutes)
- Reconstitute with bacteriostatic water, store refrigerated, use within 14 days
- Monitor: IGF-1, fasting glucose, TSH, FT4
If this is your first peptide, the order you run things in matters more than the choice: How to pick your first peptide and what to add after that.
Usage History
Pairs With
How Sermorelin behaves when it is run alongside other compounds.
Commonly stacked with
Used to offset
Stacks the risk
Marker Interactions
Compare With
Frequently Asked Questions
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Quick Reference
Category
Peptide
Half-Life
~10-12 minutes
Detection Time
N/A