Sermorelin
Synthetic GHRH analog (GRF 1-29). Stimulates natural pulsatile GH release from the pituitary. Originally FDA-approved for paediatric GH deficiency. Used off-label for anti-aging and body composition.
Overview
Synthetic GHRH analog (GRF 1-29). Stimulates natural pulsatile GH release from the pituitary. Originally FDA-approved for paediatric GH deficiency. Used off-label for anti-aging and body composition.
Increases pulsatile GH and IGF-1 levels, may mildly elevate fasting glucose (less than exogenous GH), can cause subclinical hypothyroidism in ~6.5% of users (monitor TSH/FT4), generally well tolerated on blood markers
Compound Guide
Structure: Synthetic 29-amino-acid peptide representing the bioactive fragment of native GHRH (1-44). The shortest functional GHRH sequence.
Dosage:
- Anti-aging / body composition: 200-300mcg before bed
- Standard titration: 200mcg/day (weeks 1-2) → 300mcg (weeks 3-4) → 400-500mcg (weeks 5-8)
- Combined with GHRP: 200-300mcg Sermorelin + 100-200mcg Ipamorelin before bed
Administration:
- SubQ injection at bedtime (aligns with natural nocturnal GH pulse)
- 27-30g insulin syringe
- Empty stomach preferred
Key Notes:
- One of the best-studied GH peptides — was FDA-approved (as Geref) before discontinuation for commercial reasons
- Preserves natural GH pulsatility and feedback — more physiological than exogenous GH
- Less potent than Tesamorelin or mod-GRF/CJC-1295 but well-studied safety profile
- Can cause subclinical hypothyroidism (~6.5%) — monitor thyroid panel
- Synergistic with GHRPs (Ipamorelin, GHRP-2) — GHRH + GHRP together amplifies release
- Short half-life means single daily injection is practical (GH pulse occurs within minutes)
- Reconstitute with bacteriostatic water, store refrigerated, use within 14 days
- Monitor: IGF-1, fasting glucose, TSH, FT4
Usage History
Marker Interactions
Frequently Asked Questions
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Quick Reference
Category
Peptide
Half-Life
~10-12 minutes
Detection Time
N/A