CJC-1295 no DAC (mod-GRF)
Modified GRF(1-29). Short-acting GHRH analog with four amino acid substitutions for stability. Provides pulsatile GH release. Often combined with Ipamorelin.
Overview
Modified GRF(1-29). Short-acting GHRH analog with four amino acid substitutions for stability. Provides pulsatile GH release. Often combined with Ipamorelin.
Elevates GH and IGF-1 through pulsatile release (more physiological than DAC version), minimal impact on cortisol or prolactin, may mildly elevate fasting glucose with prolonged use, generally well tolerated on blood markers
Compound Guide
Structure: Modified GRF(1-29) with four amino acid substitutions (positions 2, 8, 15, 27) that protect against enzymatic degradation. NOT the same as CJC-1295 with DAC — this version has no Drug Affinity Complex.
Dosage:
- Standard: 100-200mcg 2-3x/day SubQ
- Combined with Ipamorelin (most popular stack): 100mcg mod-GRF + 100-200mcg Ipamorelin per injection, 2-3x/day
- Before bed only: 100-200mcg for sleep-related GH pulse
Administration:
- SubQ injection, 27-30g insulin syringe
- Empty stomach (30+ min before food)
- Multiple daily injections needed due to short half-life
Key Notes:
- Preferred over CJC-1295 DAC by many users — produces natural pulsatile GH release rather than continuous elevation
- The "mod-GRF + Ipamorelin" stack is considered the gold standard peptide stack for GH optimisation
- GHRH (mod-GRF) + GHRP (Ipamorelin) together produce synergistic GH release — much more than either alone
- No GH bleed (constant elevation) — mimics natural physiology better than DAC version
- Requires multiple daily injections — less convenient than CJC-1295 DAC or MK-677
- Monitor: IGF-1, fasting glucose
- Reconstitute with bacteriostatic water, store refrigerated
IGF-1, glucose, HbA1c and cortisol on the CJC plus ipamorelin stack: How to read your labs on CJC-1295 and ipamorelin.
Usage History
Pairs With
How CJC-1295 no DAC (mod-GRF) behaves when it is run alongside other compounds.
Commonly stacked with
Stacks the risk
Marker Interactions
Compare With
CJC-1295 no DAC (mod-GRF) vs Ipamorelin
Ipamorelin vs CJC-1295 No-DAC: GHRP and GHRH explained
CJC-1295 no DAC (mod-GRF) vs MK-677 (Ibutamoren)
CJC-1295 No-DAC vs MK-677: Pulsatile vs Continuous GH Stimulation
CJC-1295 no DAC (mod-GRF) vs Tesamorelin
CJC-1295 No-DAC vs Tesamorelin: Both GHRH Analogs, Very Different Evidence Bases
Frequently Asked Questions
Related Articles
How to Pick Your First Peptide and What to Add After That
Most peptide stacks fail on sequence, not selection. A six-stage roadmap for what to run first, what to add next, and what the evidence actually supports.
Does 5-Amino-1MQ Actually Burn Fat? (No Human Trials Yet)
5-amino-1MQ is an NNMT inhibitor sold for fat loss and NAD+. Here's the real evidence, honest dosing, and the bloodwork to run on it.
Does IGF-1 LR3 Make Your Organs Grow?
IGF-1 LR3 and DES for bodybuilders: the real organ-growth and hypoglycaemia risks, what your IGF-1, glucose and insulin labs should show, and how to monitor.
MOTS-C and SS-31 for Enhanced Athletes, Labs Included
What MOTS-C and SS-31 do to your glucose, insulin, HbA1c, and CRP, the bloodwork to track, and how MOTS-C compares to MK-677. Evidence and protocol.
Quick Reference
Category
Peptide
Half-Life
~30 minutes
Detection Time
N/A