CJC-1295 no DAC (mod-GRF)
Modified GRF(1-29). Short-acting GHRH analog with four amino acid substitutions for stability. Provides pulsatile GH release. Often combined with Ipamorelin.
Overview
Modified GRF(1-29). Short-acting GHRH analog with four amino acid substitutions for stability. Provides pulsatile GH release. Often combined with Ipamorelin.
Elevates GH and IGF-1 through pulsatile release (more physiological than DAC version), minimal impact on cortisol or prolactin, may mildly elevate fasting glucose with prolonged use, generally well tolerated on blood markers
Compound Guide
Structure: Modified GRF(1-29) with four amino acid substitutions (positions 2, 8, 15, 27) that protect against enzymatic degradation. NOT the same as CJC-1295 with DAC — this version has no Drug Affinity Complex.
Dosage:
- Standard: 100-200mcg 2-3x/day SubQ
- Combined with Ipamorelin (most popular stack): 100mcg mod-GRF + 100-200mcg Ipamorelin per injection, 2-3x/day
- Before bed only: 100-200mcg for sleep-related GH pulse
Administration:
- SubQ injection, 27-30g insulin syringe
- Empty stomach (30+ min before food)
- Multiple daily injections needed due to short half-life
Key Notes:
- Preferred over CJC-1295 DAC by many users — produces natural pulsatile GH release rather than continuous elevation
- The "mod-GRF + Ipamorelin" stack is considered the gold standard peptide stack for GH optimisation
- GHRH (mod-GRF) + GHRP (Ipamorelin) together produce synergistic GH release — much more than either alone
- No GH bleed (constant elevation) — mimics natural physiology better than DAC version
- Requires multiple daily injections — less convenient than CJC-1295 DAC or MK-677
- Monitor: IGF-1, fasting glucose
- Reconstitute with bacteriostatic water, store refrigerated
Usage History
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~30 minutes
Detection Time
N/A