Cabergoline

Mechanism: Potent, long-acting dopamine D2 receptor agonist. Suppresses prolactin secretion from the pituitary. Very long half-life allows twice-weekly dosing.

Dosage:

• Prophylactic (on 19-nor cycle): 0.25 mg 2x/week
• Therapeutic (elevated prolactin): 0.25-0.5 mg 2x/week
• Only use when prolactin is confirmed elevated via blood test, or clear symptoms are present

Administration:

• Oral tablet, with or without food
• Twice-weekly dosing (e.g. Monday/Thursday)

Key Notes:

• Only needed on 19-nor cycles (Nandrolone, Trenbolone) or with confirmed elevated prolactin
• Symptoms of high prolactin: erectile dysfunction, anorgasmia, low libido, nipple discharge (rare), mood changes
• P5P (active Vitamin B6, 50-100mg/day) is a milder first-line option for mild prolactin elevation
• Very potent drug -- start low (0.25mg 2x/week) and only increase if needed
• Can cause nausea, dizziness, and fatigue, especially when first starting
• Do NOT use without confirmed indication -- unnecessary dopamine agonism is not benign
• Recheck prolactin 4-6 weeks after starting to confirm adequate control