Gamma-Glutamyl Transferase

Liver Function marker

GGT

Gamma-Glutamyl Transferase

Category: Liver Function
Unit: U/L

Enzyme involved in bile duct function. Sensitive marker for liver/bile duct issues and alcohol use.

PED Notes

Can be elevated by oral AAS. More specific to liver than AST/ALT since it's not affected by muscle damage. Good confirmatory test for liver stress vs training-induced elevation. If GGT is elevated alongside ALT/AST, liver stress is confirmed. If GGT is normal but AST/ALT are elevated, the elevation is likely from muscle damage, not liver.

When high

Supplements:

  • TUDCA -- 500-1000mg/day (with meals); first-line for GGT elevation, which typically reflects cholestatic/bile duct stress
  • NAC -- 1200-1800mg/day (empty stomach, divided doses); glutathione precursor
  • Milk Thistle / Silymarin Phytosome (Siliphos) -- 200mg 2x/day for ~10x absorption vs standard silymarin

Compound/AAS adjustments:

  • Switch oral AAS to injectable equivalents -- GGT elevation from 17-alpha-alkylated orals drops substantially on injectable-only cycles
  • Drop 17-alpha-alkylated orals (Dianabol, Anadrol, Winstrol, Anavar, Superdrol, Halotestin) if GGT is elevated alongside ALT/AST, especially with rising bilirubin
  • Proviron (mesterolone) is NOT 17-aa and does not elevate GGT meaningfully
  • Zero alcohol during oral AAS cycles; alcohol is the single biggest non-AAS driver of elevated GGT

Pharmacological options (cholestatic pattern):

  • Ursodeoxycholic acid (UDCA / Actigall) -- 10-15mg/kg/day (typically 500mg 2x/day); prescription bile acid, gold-standard for cholestatic injury; more potent than TUDCA; physician-supervised
  • Indication: GGT >3x ULN with rising bilirubin or jaundice

Lifestyle:

  • Consider reducing or dropping oral AAS if GGT is elevated alongside ALT/AST

History Chart

Reading History

Frequently Asked Questions

Reference Ranges

Standard Range

0 - 60 U/L

VitalMetrics Range

0 - 80 U/L

Statistics