NAD+ (Nicotinamide Adenine Dinucleotide)
Essential coenzyme for cellular energy production and DNA repair. Not a peptide but commonly available as injectable. Levels decline with age. Central to sirtuin activation and mitochondrial function.
Overview
Essential coenzyme for cellular energy production and DNA repair. Not a peptide but commonly available as injectable. Levels decline with age. Central to sirtuin activation and mitochondrial function.
May improve markers of metabolic health: fasting glucose, insulin sensitivity. May modulate inflammatory markers. No direct impact on hormones, lipids, or haematology at standard doses. IV infusions may cause flushing, nausea, chest tightness during administration.
Compound Guide
Structure: Dinucleotide coenzyme (not a peptide — commonly grouped with peptides commercially). Exists in oxidised (NAD+) and reduced (NADH) forms. Critical for >500 enzymatic reactions.
Dosage:
- SubQ injection: 50-200mg/day
- IV infusion (clinical setting): 250-1000mg per session, 1-4x/month
- Oral precursors (NMN): 250-1000mg/day
- Oral precursors (NR): 300-600mg/day
Administration:
- SubQ injection for regular supplementation
- IV infusion in clinical/wellness settings (more bioavailable but requires professional)
- Oral NMN or NR as accessible alternatives
Key Notes:
- NAD+ is essential for: ATP production, DNA repair (PARP enzymes), sirtuin activation (longevity/metabolism), circadian rhythm regulation
- Levels decline ~50% between ages 40-60 — supplementation aims to restore youthful levels
- Sirtuin activation (SIRT1-7) promotes: fat oxidation, mitochondrial biogenesis, inflammation reduction
- IV infusions can cause uncomfortable flushing, nausea, chest pressure — slower infusion rate helps
- SubQ injections may sting — dilute or inject slowly
- Synergises with: Resveratrol (SIRT1 activator), Metformin (AMPK), MOTS-C (mitochondrial peptide)
- Bodybuilding relevance: energy production, recovery, anti-aging, may counteract NAD+ depletion from alcohol or oxidative stress
- Monitor: no standard blood test for NAD+ levels; fasting glucose and metabolic markers may show improvement
Usage History
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~1-4 hours (injectable); oral precursors (NMN/NR) have different kinetics
Detection Time
N/A