MGF (Mechano Growth Factor)

Structure: Splice variant of IGF-1 with a unique C-terminal E domain. Native MGF has an extremely short half-life. PEGylated MGF (PEG-MGF) has an extended duration.

Dosage:

• PEG-MGF (preferred): 200-400mcg 2-3x/week, injected into target muscle post-workout
• Native MGF: 100-200mcg immediately post-workout, injected bilaterally into trained muscle
• Cycle: 4-6 weeks on, 4 weeks off

Administration:

• IM injection directly into the trained muscle (localised effect)
• 27-30g insulin syringe, 0.5-1 inch depth
• Inject within 10 min of finishing training the target muscle group

Key Notes:

• Primary mechanism: activates satellite cells (muscle stem cells) — promotes hyperplasia, not just hypertrophy
• Native MGF has an extremely short half-life (~5-7 min) — PEG-MGF is preferred for practical use
• Must be injected into the target muscle — systemic SubQ injection provides minimal benefit
• Works best in a damaged/trained muscle (mechano-sensitive response)
• Limited human clinical data — most research is preclinical
• Does not significantly impact standard blood panels
• Reconstitute with bacteriostatic water, use immediately (native) or within 30 days (PEG-MGF)

Where MGF sits against IGF-1 LR3 on evidence and monitoring: Does IGF-1 LR3 make your organs grow?.