MGF (Mechano Growth Factor)
Mechano Growth Factor. Splice variant of IGF-1 (IGF-1Ec) produced in response to mechanical stress. Activates satellite cells for localised muscle repair and growth.
Overview
Mechano Growth Factor. Splice variant of IGF-1 (IGF-1Ec) produced in response to mechanical stress. Activates satellite cells for localised muscle repair and growth.
No significant direct impact on standard blood markers. Does not elevate systemic IGF-1 significantly at typical doses. Does not affect hormones, lipids, or haematology. Primarily acts locally at injection site. Limited human data.
Compound Guide
Structure: Splice variant of IGF-1 with a unique C-terminal E domain. Native MGF has an extremely short half-life. PEGylated MGF (PEG-MGF) has an extended duration.
Dosage:
- PEG-MGF (preferred): 200-400mcg 2-3x/week, injected into target muscle post-workout
- Native MGF: 100-200mcg immediately post-workout, injected bilaterally into trained muscle
- Cycle: 4-6 weeks on, 4 weeks off
Administration:
- IM injection directly into the trained muscle (localised effect)
- 27-30g insulin syringe, 0.5-1 inch depth
- Inject within 10 min of finishing training the target muscle group
Key Notes:
- Primary mechanism: activates satellite cells (muscle stem cells) — promotes hyperplasia, not just hypertrophy
- Native MGF has an extremely short half-life (~5-7 min) — PEG-MGF is preferred for practical use
- Must be injected into the target muscle — systemic SubQ injection provides minimal benefit
- Works best in a damaged/trained muscle (mechano-sensitive response)
- Limited human clinical data — most research is preclinical
- Does not significantly impact standard blood panels
- Reconstitute with bacteriostatic water, use immediately (native) or within 30 days (PEG-MGF)
Usage History
Markers to Monitor
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~5-7 minutes (native) / 24-48h (PEG-MGF)
Detection Time
N/A