KPV
Lysine-Proline-Valine. Anti-inflammatory tripeptide derived from alpha-MSH. Potent NF-kB inhibitor. Used for gut inflammation (IBD), skin conditions, and systemic inflammation.
Overview
Lysine-Proline-Valine. Anti-inflammatory tripeptide derived from alpha-MSH. Potent NF-kB inhibitor. Used for gut inflammation (IBD), skin conditions, and systemic inflammation.
May reduce inflammatory markers (CRP, IL-6, TNF-alpha) through NF-kB pathway inhibition. No significant direct impact on hormones, lipids, liver enzymes, or haematology. No melanotropic (tanning) effects despite alpha-MSH origin.
Compound Guide
Structure: C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Retains anti-inflammatory activity without melanocortin receptor activation (no tanning effect).
Dosage:
- Gut inflammation: 200-500mcg/day SubQ or oral
- Standard titration: 200mcg/day (week 1) → 300mcg (week 2) → 400-500mcg (weeks 3-8)
- Oral (gut-specific): 200-500mcg/day in capsule form
Administration:
- SubQ injection for systemic anti-inflammatory effect
- Oral for gut-targeted inflammation (IBD, colitis, leaky gut)
- 27-30g insulin syringe for SubQ
Key Notes:
- Potent inhibitor of NF-kB — the master inflammatory transcription factor
- Reduces pro-inflammatory cytokines: TNF-alpha, IL-6, IL-1beta
- Popular for inflammatory bowel conditions — can be taken orally for direct gut action
- No melanocortin receptor activation — does not cause tanning, appetite changes, or libido effects
- Often stacked with BPC-157 for gut healing (BPC-157 heals tissue, KPV reduces inflammation)
- Very well tolerated — minimal systemic side effects
- May help reduce elevated CRP in users with chronic inflammation
- Reconstitute with bacteriostatic water, store refrigerated
Usage History
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
Unknown
Detection Time
N/A