KPV
Lysine-Proline-Valine. Anti-inflammatory tripeptide derived from alpha-MSH. Potent NF-kB inhibitor. Used for gut inflammation (IBD), skin conditions, and systemic inflammation.
Overview
Lysine-Proline-Valine. Anti-inflammatory tripeptide derived from alpha-MSH. Potent NF-kB inhibitor. Used for gut inflammation (IBD), skin conditions, and systemic inflammation.
May reduce inflammatory markers (CRP, IL-6, TNF-alpha) through NF-kB pathway inhibition. No significant direct impact on hormones, lipids, liver enzymes, or haematology. No melanotropic (tanning) effects despite alpha-MSH origin.
Compound Guide
Structure: C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Retains anti-inflammatory activity without melanocortin receptor activation (no tanning effect).
Dosage:
- Gut inflammation: 200-500mcg/day SubQ or oral
- Standard titration: 200mcg/day (week 1) → 300mcg (week 2) → 400-500mcg (weeks 3-8)
- Oral (gut-specific): 200-500mcg/day in capsule form
Administration:
- SubQ injection for systemic anti-inflammatory effect
- Oral for gut-targeted inflammation (IBD, colitis, leaky gut)
- 27-30g insulin syringe for SubQ
Key Notes:
- Potent inhibitor of NF-kB — the master inflammatory transcription factor
- Reduces pro-inflammatory cytokines: TNF-alpha, IL-6, IL-1beta
- Popular for inflammatory bowel conditions — can be taken orally for direct gut action
- No melanocortin receptor activation — does not cause tanning, appetite changes, or libido effects
- Often stacked with BPC-157 for gut healing (BPC-157 heals tissue, KPV reduces inflammation)
- Very well tolerated — minimal systemic side effects
- May help reduce elevated CRP in users with chronic inflammation
- Reconstitute with bacteriostatic water, store refrigerated
Important caveat on route: every study showing an effect on gut inflammation used the oral or rectal route, because KPV is carried into inflamed gut tissue by the PepT1 transporter. No study has tested subcutaneous KPV for any inflammatory outcome. Full evidence review: Does KPV peptide actually calm inflammation in the gut?.
Usage History
Pairs With
How KPV behaves when it is run alongside other compounds.
Commonly stacked with
Used to offset
Stacks the risk
Marker Interactions
Frequently Asked Questions
Related Articles
Does KPV Peptide Actually Calm Inflammation in the Gut?
KPV peptide for gut inflammation: the FDA compounding vote, the mouse evidence, oral versus subq dosing, and which bloodwork markers actually matter.
How to Pick Your First Peptide and What to Add After That
Most peptide stacks fail on sequence, not selection. A six-stage roadmap for what to run first, what to add next, and what the evidence actually supports.
Quick Reference
Category
Peptide
Half-Life
Unknown
Detection Time
N/A