Kisspeptin
Neuroendocrine peptide that stimulates GnRH release. Upstream regulator of the entire HPTA axis. Used for fertility support and HPTA recovery. Alternative to Gonadorelin and HCG.
Overview
Neuroendocrine peptide that stimulates GnRH release. Upstream regulator of the entire HPTA axis. Used for fertility support and HPTA recovery. Alternative to Gonadorelin and HCG.
Stimulates pulsatile GnRH → LH/FSH release → testosterone and estradiol production. May raise LH, FSH, testosterone. Does not directly affect liver enzymes or lipids. Acts upstream of Gonadorelin in the HPTA cascade.
Compound Guide
Structure: Endogenous neuropeptide. Kisspeptin-10 (10 amino acid fragment) is most commonly used. Binds GPR54 (KISS1R) receptor on GnRH neurons in the hypothalamus.
Dosage:
- HPTA support / fertility: 100-200mcg/day SubQ
- Standard titration: 100mcg/day (weeks 1-2) → 200mcg/day (weeks 3-12)
- Cycle: 8-12 weeks; avoid continuous use to prevent tachyphylaxis (receptor desensitisation)
Administration:
- SubQ injection, once daily
- 27-30g insulin syringe
- Morning dosing preferred to align with natural LH pulsatility
Key Notes:
- Acts at the very top of the HPTA cascade: Kisspeptin → GnRH → LH/FSH → Testosterone
- More physiological HPTA stimulation than HCG (which bypasses pituitary) or Gonadorelin (which bypasses hypothalamus)
- May help restore HPTA function post-AAS by reactivating the hypothalamic signaling that AAS suppresses
- Used clinically for IVF trigger (reduces ovarian hyperstimulation risk vs HCG)
- Can cause tachyphylaxis with continuous use — cycle on/off or use intermittently
- Emerging peptide in bodybuilding PCT protocols — less established than HCG/SERMs
- Monitor: LH, FSH, total/free testosterone, E2
- Reconstitute with bacteriostatic water, store refrigerated
Usage History
Markers to Monitor
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~28 minutes (Kisspeptin-10) / ~4 minutes (Kisspeptin-54)
Detection Time
N/A