Gonadorelin
Synthetic GnRH (Gonadotropin-Releasing Hormone). Used to maintain LH/FSH production and testicular function during AAS cycles. Alternative to HCG.
Overview
Synthetic GnRH (Gonadotropin-Releasing Hormone). Used to maintain LH/FSH production and testicular function during AAS cycles. Alternative to HCG.
Stimulates endogenous LH and FSH release from the pituitary (unlike HCG which mimics LH directly), helps maintain testicular function on cycle, may partially preserve intratesticular testosterone, less estradiol elevation compared to HCG
Compound Guide
Structure: Synthetic decapeptide identical to endogenous GnRH (also called LHRH). Stimulates the pituitary to release both LH and FSH.
Dosage:
- On-cycle testicular maintenance: 100-200mcg 2x/day SubQ
- HPTA support: 100mcg 2x/day
- Some protocols use pulsatile dosing: 100mcg every 2-4 hours via pump (clinical setting)
Administration:
- SubQ injection, 27-30g insulin syringe
- Must be dosed frequently due to very short half-life — minimum 2x/day
- Morning and evening dosing schedule
Key Notes:
- Acts upstream of HCG — stimulates your own pituitary to release LH/FSH rather than injecting exogenous LH-mimetic
- Maintains more of the natural HPTA signaling cascade compared to HCG
- Less estradiol spike compared to HCG (which can cause E2 surges)
- Requires frequent dosing — less convenient than HCG (which is dosed 2-3x/week)
- Becoming more popular as HCG availability has become restricted in some countries
- Does not desensitise Leydig cells the way chronic high-dose HCG can
- Monitor: LH, FSH, testosterone, E2 — to verify pituitary response
Usage History
Markers to Monitor
Marker Interactions
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
2-4 minutes (requires frequent dosing)
Detection Time
N/A