Epithalon

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on epithalamin from the pineal gland. Activates telomerase. Stimulates melatonin production. Used for anti-aging and longevity.

Overview

Peptide

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on epithalamin from the pineal gland. Activates telomerase. Stimulates melatonin production. Used for anti-aging and longevity.

Effects on Markers

May normalise melatonin and cortisol circadian rhythms. No significant direct impact on standard blood markers, hormones, lipids, or liver enzymes. Animal studies show reduced tumour incidence and improved cardiovascular markers over long-term use.

Compound Guide

Structure: Synthetic tetrapeptide (Ala-Glu-Asp-Gly). Mimics the active component of epithalamin, a pineal gland extract studied by Professor Vladimir Khavinson.

Dosage:

  • Standard anti-aging protocol: 5mg/day SubQ for 20 consecutive days, repeated every 4-6 months (2 cycles/year)
  • Conservative: 5mg/day for 10 days, 2-3 cycles/year
  • Alternative: 5-10mg 3x/week for 4-6 weeks

Administration:

  • SubQ injection, evening preferred (aligns with melatonin rhythm)
  • 27-30g insulin syringe
  • Cycled protocol — not for continuous use

Key Notes:

  • Primary mechanism: activates telomerase → lengthens telomeres → cellular longevity
  • Stimulates nocturnal melatonin secretion from the pineal gland — restores circadian rhythm in aging individuals
  • Animal studies (rats): 25% lifespan extension, reduced tumour incidence, improved cardiovascular markers
  • 12-year human follow-up study showed reduced cardiovascular mortality in elderly subjects
  • Bodybuilding relevance: longevity/health optimisation, improved sleep quality (melatonin), potential anti-cancer protection during long-term PED use
  • Very well tolerated — no serious adverse events in published studies
  • Cycled protocol (20 days on, months off) is the established approach
  • No significant impact on standard blood panels
  • Reconstitute with bacteriostatic water, store refrigerated

Usage History

Markers to Monitor

Frequently Asked Questions

Quick Reference

Category

Peptide

Half-Life

Unknown (short peptide; effects are genomic — telomerase activation persists)

Detection Time

N/A

Usage Summary