DSIP (Delta Sleep Inducing Peptide)
Nonapeptide first isolated from rabbit brain. Promotes delta-wave (deep) sleep without sedation. May modulate the HPA axis for stress protection.
Overview
Nonapeptide first isolated from rabbit brain. Promotes delta-wave (deep) sleep without sedation. May modulate the HPA axis for stress protection.
May modulate cortisol levels (stress-protective HPA axis effects). Does not significantly affect hormones, lipids, liver enzymes, or haematology at standard doses. No pharmacological tolerance reported with continued use.
Compound Guide
Structure: Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Naturally occurring in the brain. Modulates GABAergic transmission and opioid receptor systems.
Dosage:
- Sleep support: 100-300mcg before bed
- Standard titration: 100mcg (week 1) → 150mcg (week 2) → 200-300mcg (weeks 3-8)
- Cycle: 4-8 weeks on, 2-4 weeks off
Administration:
- SubQ injection, 30-60 min before bed
- 27-30g insulin syringe
- Take in a relaxed environment to maximise sleep onset
Key Notes:
- Increases delta-wave (slow-wave, stage 3) sleep — the most restorative sleep phase
- Does not significantly alter REM sleep — preserves normal sleep architecture
- Not a sedative — does not cause drowsiness or impair cognition
- No pharmacological tolerance with continued use (unlike benzodiazepines or Z-drugs)
- May have stress-protective effects via HPA axis modulation — reduces cortisol response to stress
- Bodybuilding relevance: deeper sleep → more GH release, better recovery, lower cortisol
- Well tolerated — no significant side effects reported in clinical studies
- Reconstitute with bacteriostatic water, store refrigerated
- Monitor: cortisol (if concerned about HPA axis effects)
Usage History
Markers to Monitor
Pairs With
How DSIP (Delta Sleep Inducing Peptide) behaves when it is run alongside other compounds.
Commonly stacked with
Used to offset
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~15-25 minutes
Detection Time
N/A