DSIP (Delta Sleep Inducing Peptide)
Nonapeptide first isolated from rabbit brain. Promotes delta-wave (deep) sleep without sedation. May modulate the HPA axis for stress protection.
Overview
Nonapeptide first isolated from rabbit brain. Promotes delta-wave (deep) sleep without sedation. May modulate the HPA axis for stress protection.
May modulate cortisol levels (stress-protective HPA axis effects). Does not significantly affect hormones, lipids, liver enzymes, or haematology at standard doses. No pharmacological tolerance reported with continued use.
Compound Guide
Structure: Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Naturally occurring in the brain. Modulates GABAergic transmission and opioid receptor systems.
Dosage:
- Sleep support: 100-300mcg before bed
- Standard titration: 100mcg (week 1) → 150mcg (week 2) → 200-300mcg (weeks 3-8)
- Cycle: 4-8 weeks on, 2-4 weeks off
Administration:
- SubQ injection, 30-60 min before bed
- 27-30g insulin syringe
- Take in a relaxed environment to maximise sleep onset
Key Notes:
- Increases delta-wave (slow-wave, stage 3) sleep — the most restorative sleep phase
- Does not significantly alter REM sleep — preserves normal sleep architecture
- Not a sedative — does not cause drowsiness or impair cognition
- No pharmacological tolerance with continued use (unlike benzodiazepines or Z-drugs)
- May have stress-protective effects via HPA axis modulation — reduces cortisol response to stress
- Bodybuilding relevance: deeper sleep → more GH release, better recovery, lower cortisol
- Well tolerated — no significant side effects reported in clinical studies
- Reconstitute with bacteriostatic water, store refrigerated
- Monitor: cortisol (if concerned about HPA axis effects)
Usage History
Markers to Monitor
Frequently Asked Questions
Quick Reference
Category
Peptide
Half-Life
~15-25 minutes
Detection Time
N/A