Lipoprotein Insulin Resistance Index
Lipids marker
LP-IR Score
Lipoprotein Insulin Resistance Index
NMR-derived composite score (0-100) reflecting insulin resistance based on lipoprotein particle sizes and concentrations. Higher scores indicate greater insulin resistance.
PED Notes
GH use induces insulin resistance, directly elevating the LP-IR score. Exogenous insulin use (common in advanced bodybuilding) creates a complex picture — insulin sensitivity may be adequate but the lipoprotein profile reflects resistance patterns. Bulking phases with high carbohydrate intake worsen LP-IR. AAS themselves have variable effects on insulin sensitivity, but the combined GH + AAS + high-calorie diet profile commonly seen in bodybuilders often produces elevated LP-IR scores. This marker integrates information from VLDL, LDL, and HDL particle sizes and subclass concentrations.
Understanding LP-IR Score:
- 0-27: Low insulin resistance risk
- 28-44: Moderate risk
- 45-100: High insulin resistance risk
- Integrates 6 NMR lipoprotein measures into a single score
If Elevated (>45):
- Assess GH dosage — consider reducing if LP-IR persistently elevated
- Check fasting glucose, insulin, and HbA1c to confirm insulin resistance
- Monitor for progression toward metabolic syndrome
Supplements:
- Berberine -- 500mg 2-3x/day (improves insulin sensitivity)
- Omega-3 (EPA/DHA) -- 2-4g/day
- Chromium Picolinate -- 200-400mcg/day
Lifestyle:
- Reduce refined carbohydrates
- Increase fibre intake
- Regular cardio exercise (improves insulin sensitivity)
- If on GH + insulin, work closely with a physician experienced in metabolic management
References:
- Shalaurova, I., Connelly, M. A., Garvey, W. T., & Otvos, J. D. (2014). Lipoprotein insulin resistance index: A lipoprotein particle-derived measure of insulin resistance. Metabolic Syndrome and Related Disorders, 12(8), 422-429. DOI: 10.1089/met.2014.0050
- Mora, S., Otvos, J. D., Rosenson, R. S., et al. (2016). Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women. Diabetes, 59(5), 1153-1160. DOI: 10.2337/db09-1114
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