Mean Platelet Volume

When elevated (>13.0 fL -- large, young platelets):

• Indicates increased platelet turnover -- bone marrow producing larger, more reactive platelets to compensate for destruction or consumption
• High MPV + low platelet count = platelets being consumed/destroyed faster than produced (investigate immune thrombocytopenia, chronic inflammation)
• High MPV + normal platelet count = usually benign, may reflect recent intense training
• Elevated MPV is an independent cardiovascular risk marker in some studies (larger platelets are more thrombogenic)

When low (<7.0 fL -- small, old platelets):

• May indicate bone marrow underproduction (aplastic conditions) or certain inflammatory states
• Low MPV + low platelets = possible bone marrow issue -- warrants haematology referral
• Low MPV + normal platelets = usually not clinically significant

Note: MPV is most useful when interpreted alongside platelet count rather than in isolation. No specific supplements directly target MPV.

References:

• Marchioli, R., Finazzi, G., Specchia, G., et al. (2013). Cardiovascular events and intensity of treatment in polycythemia vera. New England Journal of Medicine, 368(1), 22-33. DOI: 10.1056/NEJMoa1208500